
Shop decision
When this relic shows up — buy, hold, or skip.
- Best for
- Best for boards that already fire the keywords on this relic built around Burn, Poison, and Frost.
- Skip when
- Skip when you rarely trigger Burn, Poison, and Frost, or a cheaper enabler would stabilize the board first.
- Shop note
- Unique late luxury. Prefer it when the board already leans this direction. Stack Burn, Poison, and Frost support around it.
Synergies
Relics that share combat tags with this one — useful pairing candidates.

Duelist's Rhythm Prism
Epic
Whenever a Duelist auto attacks, they randomly inflict 1 Poison, 0 Frost, or 0 Burn on their target.
Duelist
Poison
Frost

Plague Ascendancy
Epic
Inflict 25 Poison, 50 Frost, and 75 Burn on a single enemy. At start of Combat, inflict 75 Poison, 50 Frost, and 25 Burn on all enemies.
Poison
Frost
Burn

Plague Generator
Common
At start of combat, inflict 1 Poison, 1 Frost, and 1 Burn on all enemies.
Poison
Frost
Burn

Plague Transmission Engine
Legendary
At start of combat and every 1 seconds, inflict 1 Poison, 1 Frost, and 10 Burn on all enemies.
Poison
Frost
Burn

Blight Resonance Prism
Epic
Whenever an enemy takes Poison or Burn damage, heal all adjacent Heroes to them for 100% of that damage.
Poison
Burn
Heal

Glacial Decay Engine
Legendary
Frost now deals damage to enemies when it ticks down (like Burn does).
Frost
Burn