Shop decision
When this relic shows up — buy, hold, or skip.
- Best for
- Best as a power spike on Duelist boards once the core loop is online.
- Skip when
- Skip when you are not running Duelist, or you rarely trigger Poison, Frost, and Burn.
- Shop note
- Epic mid–late power spike. Prefer it when the board already leans this direction. Stack Poison, Frost, and Burn support around it.
Synergies
Relics that share combat tags with this one — useful pairing candidates.
Plague Ascendancy
Epic
Inflict 25 Poison, 50 Frost, and 75 Burn on a single enemy. At start of Combat, inflict 75 Poison, 50 Frost, and 25 Burn on all enemies.
Poison
Frost
Burn
Plague Bauble
Unique
At start of combat, inflict 3 Poison, inflict 6 Frost, inflict 9 Burn on enemies
Burn
Poison
Frost
Plague Generator
Common
At start of combat, inflict 1 Poison, 1 Frost, and 1 Burn on all enemies.
Poison
Frost
Burn
Plague Transmission Engine
Legendary
At start of combat and every 1 seconds, inflict 1 Poison, 1 Frost, and 10 Burn on all enemies.
Poison
Frost
Burn
Blight Resonance Prism
Epic
Whenever an enemy takes Poison or Burn damage, heal all adjacent Heroes to them for 100% of that damage.
Poison
Burn
Heal
Duelist's Chill Banner
Unique
Whenever a Duelist auto attacks, they inflict 1 Frost on their target.
Duelist
Frost