
Poison Ascendancy
Inflict 400 Poison. The first time each enemy reaches 50 Poison, they lose 33% Max HP, 66% Attack, and 66% Attack Speed.
Shop decision
When this relic shows up — buy, hold, or skip.
- Best for
- Best as a late luxury when built around Poison and you can afford a high-rarity slot.
- Skip when
- Skip when you rarely trigger Poison.
- Shop note
- Epic late luxury. Prefer it when the board already leans this direction. Stack Poison support around it.
Synergies
Relics that share combat tags with this one — useful pairing candidates.

Vanguard's Frenzy Prism
Whenever a Vanguard goes below 100% Max HP for the first time each combat they gain +0% Attack Speed, +0% Attack, and +50% Defense.

Acceleration Fluctuator
On Rush trigger, +10 Attack, +10 Attack Speed on nearby allies

Burn Vessel
Inflict 300 Burn. Heroes gain 200 Max HP and 25 Attack.

Critical Singularity
At start of combat, each Hero with less than 1 Crit has their Crit set to 0. Each Hero with 0 or more Crit has their Attack Speed, Attack, and Magic set to {3} if they had less than {4} of those stats.

Deceleration Fluctuator
On Stall trigger, +10 Magic, +10 Attack Speed on nearby allies

Duelist's Combative Reflection
Duelists gain 20 Attack Speed and 25 Attack.